Q. 7. Based on your understanding of genetic code, explain the formation of any abnormal hemoglobin molecule. What are the known consequences of such a change?
Due to point mutation in -globin chain of the hemoglobin molecule, glutamic acid (Glu) is replaced by valine (Val) at the sixth position.
Under stress condition erythrocytes lose their circular shape and become sickle-shaped. As a result, the cells cannot pass through narrow capillaries. Blood capillaries are clogged and thus affect blood supply to different organs.
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