Statement I: | Concentrated urine is formed due to counter current mechanism in nephron. |
Statement II: | Counter current mechanism helps to maintain osmotic gradient in the medullary interstitium. |
Which of the following factors is responsible for the formation of concentrated urine?
1. | Hydrostatic pressure during glomerular filtration. |
2. | Low levels of antidiuretic hormone. |
3. | Maintaining hyperosmolarity towards inner medullary interstitium in the kidneys. |
4. | Secretion of erythropoietin by Juxtaglomerular complex. |