Sickle cell anaemia has not been eliminated from the African population because:
1. It is controlled by recessive genes
2. It is not a fatal disease
3. It provides immunity against malaria
4. It is controlled by dominant genes
The genetic change shown in the given figure shows the pathogenesis of:
1. | Phenylketonuria | 2. | Cystic fibrosis |
3. | Sickle cell anemia | 4. | Thalassemia |
Given below is the initial amino acids of the beta chain of a haemoglobin molecule. What will be true about this haemoglobin molecule?
1. | The RBCs carrying this molecule will undergo sickling at a high oxygen tension |
2. | The RBCs carrying this molecule will undergo sickling at a low oxygen tension |
3. | There will be a quantitative decrease in the synthesis of this molecule |
4. | This is the normal beta chain of the haemoglobin molecule |
Given below [A – E] are suggested causes for the genetic diseases. Select the cause as your answer for the given disease.
A. | A single nucleotide mutation results in a polar amino acid being substituted by a non-polar amino acid in the polypeptide. |
B. | Autosomal recessive inborn error of metabolism where mutation renders a key enzyme involved in amino acid metabolism non-functional. |
C. | X-linked recessive condition is more common in males than in females. |
D. | Caused by a primary autosomal non-disjunction event. |
E. | Caused by a non-disjunction event in sex chromosomes in either of the sexes. |
Sickle cell anaemia:
1. | A | 2. | B |
3. | C | 4. | D |