- 1(current)
Q. No.Mental retardation in man occurs due to:
1. Loss of one X chromosome
2. Addition of one X chromosome
3. Slight growth in Y
4. Overgrowth in Y
Consider the following statements:
| I: | People affected by phenylketonuria are unable to convert tyrosine to phenylalanine. |
| II: | Alzheimer’s disease results from the accumulation of amyloid protein plaques in the brain. |
| III: | Klinefelter’s and Turner’s syndromes are the result of nondisjunction of the sex chromosomes in either of the sexes. |
Which of the above statements are true?
| 1. | I and II only | 2. | I and III only |
| 3. | II and III only | 4. | I, II, and III |
Which of the following would not be a feature seen in a patient with the following karyotype?
1. Many loops on fingertips
2. Congenital heart disease
3. Big and wrinkled tongue
4. Mucus clogging of airways
Nondisjunction of a pair of homologous chromosomes occurs during the anaphase of meiosis I. The four gametes produced as a result of this nondisjunction event will be:
| 1. | n + 1; n + 1; n - 1; n - 1 | 2. | n + 1; n - 1; n; n |
| 3. | n + 1; n - 1; n - 1; n - 1 | 4. | n + 1; n + 1; n; n |
Conditions of a karyotype 2n +1, 2n –1 and 2n + 2, 2n – 2 are called:
| 1. | Aneuploidy | 2. | Polyploidy |
| 3. | Allopolyploidy | 4. | Monosomy |
Given below [A – E] are suggested causes for the genetic diseases. Select the cause as your answer for the given disease.
| A. | A single nucleotide mutation results in a polar amino acid being substituted by a non-polar amino acid in the polypeptide. |
| B. | Autosomal recessive inborn error of metabolism where mutation renders a key enzyme involved in amino acid metabolism non-functional. |
| C. | X-linked recessive condition is more common in males than in females. |
| D. | Caused by a primary autosomal non-disjunction event. |
| E. | Caused by a non-disjunction event in sex chromosomes in either of the sexes. |
Down’s syndrome:
| 1. | A | 2. | B |
| 3. | D | 4. | E |
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Q. No.
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