Q. No.Choose the correct option regarding Retrovirus:
| 1. | An RNA virus that synthesises DNA during infection |
| 2. | A DNA virus that synthesises RNA during infection |
| 3. | A ssDNA virus |
| 4. | A dsRNA virus |
Subtopic: Gene Therapy | Molecular Diagnosis |
73%
Level 2: 60%+
Hints
A direct target for gene therapy would include all the following cells except:
| 1. | erythrocytes | 2. | muscle fibers |
| 3. | hepatocytes | 4. | vascular endothelium |
Subtopic: Gene Therapy |
Level 3: 35%-60%
Hints
The first recombinant therapeutic product approved for human use was:
| 1. | Humulin | 2. | hGH |
| 3. | Factor VIII clotting factor | 4. | Erythropoietin |
Subtopic: Gene Therapy | Molecular Diagnosis |
92%
Level 1: 80%+
Hints
The first clinical gene therapy was done for the treatment of:
| 1. | AIDS |
| 2. | Cancer |
| 3. | Cystic fibrosis |
| 4. | SCID (Severe Combined Immuno Deficiency) resulting from deficiency of ADA |
Subtopic: Gene Therapy |
94%
Level 1: 80%+
Hints
Electroporation is:
| 1. | the process of separating charged molecules through a gel maintained in an electric field |
| 2. | the process of combining foreign DNA to an electrically charged vector molecule |
| 3. | the process of introducing DNA into cells by the application of high-voltage pulses |
| 4. | the process of protoplast fusion by the application of high-voltage pulses |
Subtopic: Gene Therapy |
50%
Level 3: 35%-60%
Hints
Which of the following genetic disease would be amenable to genetic engineering?
| 1. | Down's syndrome | 2. | Muscular dystrophy |
| 3. | Cystic fibrosis | 4. | Cri du Chat |
Subtopic: Gene Therapy |
Level 3: 35%-60%
Hints
α -1 antitrypsin is:
1. An antacid
2. An enzyme
3. Used to treat arthritis
4. Used to treat emphysema
1. An antacid
2. An enzyme
3. Used to treat arthritis
4. Used to treat emphysema
Subtopic: Gene Therapy | Vaccines |
90%
Level 1: 80%+
Hints
Which of the following is one of the technical reasons why gene therapy is problematic?
| 1. | Most cells with an engineered gene do not produce gene products. |
| 2. | Most cells with engineered genes overwhelm other cells in a tissue. |
| 3. | Cells with transferred genes are unlikely to replicate. |
| 4. | Transferred genes may not have appropriately controlled activity. |
Subtopic: Gene Therapy |
Level 3: 35%-60%
Hints
Consider the two statements:
| I: | Diseases such as sickle cell disease that are caused by autosomal recessive disorders may be a good candidate for gene therapy treatment. |
| II: | For such disorders, a person's normal phenotype or cell function may be restored in cells that have the disease by a normal copy of the gene that is mutated. |
| 1. | Both I and II are correct and II explains I |
| 2. | Both I and II are correct but II does not explain I |
| 3. | I is correct but II is incorrect |
| 4. | Both I and II are incorrect |
Subtopic: Gene Therapy |
69%
Level 2: 60%+
Please attempt this question first.
Hints
| Assertion(A): | Delivery of ADA cDNA into lymphocytes is not a permanent cure for ADA deficiency |
| Reason(R) | Lymphocytes do not express ADA gene. |
| 1. | Both (A) and (R) are True and (R) is the correct explanation of the (A) |
| 2. | Both (A) and (R) are True but (R) is not the correct explanation of the (A) |
| 3. | (A) is True but (R) is False |
| 4. | Both (A) and (R) are False |
Subtopic: Gene Therapy |
64%
Level 2: 60%+
Please attempt this question first.
Hints
Please attempt this question first.
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