List I | List II | ||
A. | \(\alpha-1\) antitrypsin | I. | Cotton bollworm |
B. | Cry IAb | II. | ADA deficiency |
C. | Cry IAc | III. | Emphysema |
D. | Enzyme replacement therapy | IV. | Corn borer |
List-I | List-II | ||
(A) | Gene therapy | (I) | Separation of DNA fragments |
(B) | RNA interference | (II) | Diagnostic test for AIDS |
(C) | ELISA | (III) | Cellular defense |
(D) | Gel Electrophoresis | (IV) | Allows correction of a gene defect |
Options: | (A) | (B) | (C) | (D) |
1. | IV | I | II | III |
2. | IV | II | III | I |
3. | IV | III | II | I |
4. | IV | III | I | II |
The genetic defect-Adenosine Deaminase (ADA) deficiency may be cured permanently by:
1. | periodic infusion of genetically engineered lymphocytes having functional ADA cDNA |
2. | administering adenosine deaminase activators |
3. | introducing bone marrow cells producing ADA into cells at early embryonic stages |
4. | invitro cell culture therapy |
The site of production of ADA in the body is:
1. erythrocytes
2. lymphocytes
3. blood plasma
4. osteocytes
The first clinical gene therapy was done for the treatment of
1. | AIDS |
2. | Cancer |
3. | Cystic fibrosis |
4. | SCID (Severe Combined Immuno Deficiency resulting from the deficiency of ADA |
ADA is an enzyme which is deficient in a genetic disorder SCID. What is the full form of ADA?
1. Adenosine deoxyaminase
2. Adenosine deaminase
3. Aspartate deaminase
4. Arginine deaminase
1. | Genetically engineered lymphocytes are not immortal cells. |
2. | Retroviral vector is introduced into these lymphocytes. |
3. | Gene isolated from marrow cells producing ADA is introduced into cells at embryonic stages |
4. | Lymphocytes from patient's blood are grown in culture, outside the body. |
When gene targeting involving gene amplification is attempted in an individual's tissue to treat disease, it is known as:
1. Molecular diagnosis
2. Safety testing
3. Biopiracy
4. Gene therapy
The Adenosine deaminase deficiency results into:
1. | Digestive disorder | 2. | Addison's disease |
3. | Dysfunction of Immune system | 4. | Parkinson's disease |
Match the following columns and select the correct option.
Column-I | Column-II | ||
a. | Bt cotton | (i) | Gene therapy |
b. | Adenosine deaminase deficiency | (ii) | Cellular defense |
c. | RNAi | (iii) | Detection of HIV infection |
d. | PCR | (iv) | Bacillus thuringiensis |
a | b | c | d | |
1. | (iii) | (ii) | (i) | (iv) |
2. | (ii) | (iii) | (iv) | (i) |
3. | (i) | (ii) | (iii) | (iv) |
4. | (iv) | (i) | (ii) | (iii) |