Which one of the following statements is incorrect?
1. In competitive inhibition, the inhibitor molecule is not chemically changed by the enzyme.
2. The competitive inhibitor does not affect the rate of breakdown of the enzyme-substrate complex.
3. The presence of the competitive inhibitor decreases the Km of the enzyme for the substrate.
4. A competitive inhibitor reacts reversibly with the enzyme to form an enzyme-inhibitor complex.

Given below is a schematic metabolic pathway. In an experiment, the concentration of enzyme 1 was increased but the concentration of enzymes 2 and 3 were kept constant. What would happen to the rate of production of D?

1. it would go down
2. it would go up
3. it would stay the same
4. it would stop

If an non active-site directed inhibitor is present in the medium, the curve that will represent the progress of the chemical reaction will be shown by the letter:

1. D
2. C
3. B
4. A

All the following assumptions apply to Michaelis-Menten kinetic analyses of enzyme action EXCEPT:
1. the total enzyme concentration studied at each substrate concentration is fixed in analysis of enzyme kinetics.
2. formation of enzyme-substrate complex does not appreciably decrease the concentration of substrate.
3. Km decreases with competitive inhibition.
4. maximal velocity is reached when the enzyme-substrate complex is equal to the total concentration of enzyme present.

All of the following are true of protein denaturation except that it
1. is a shape change
2. is always irreversible
3. may be caused by a pH change
4. could result from a temperature change

Consider the given two statements:
I. The rate determining step for an enzyme-substrate reaction is always the second step in which [ES] is converted into the product.
II. Once the enzyme performs its duty, it is free to do more work.

1. Both I and II are correct and II explains I
2. Both I and are correct but II does not explain I
3. I is correct and II is incorrect
4. Both I and II are incorrect

An enzyme catalyzed reaction has a △G of -30 Kcal/mol. The amount of enzyme is doubled. What will be the △G for the new reaction?
1. -60 kcal/mol
2. -30 kcal/mol
3. +30 kcal/mol
4. +60 kcal/mol

If you compare the Km values for the enzymes that remove glucose from the blood in liver and brain, you expect that:
1. the value will be higher for the enzyme found in brain
2. the value will be exactly ten times lower for the enzyme found in liver
3. the values for two enzymes will be same
4. the value will be lower for the enzyme found in brain

The compound from which cholesterol is formed is:
1. Mevalonic acid
2. Butyric acid
3. Alpha ketoglutaric acid
4. Acetic acid

Match Amino acids in COLUMN I with their non-protein functions [precursors of] in COLUMN II and select the correct answer from the codes given:

Codes
    A B C D
1. P Q R S
2. Q P S R
3. P Q S R
4. S R Q P