In which of the following one may observe variation in DNA?
(1) Fragmentation
(2) Budding
(3) Amitosis
(4) mutation
Two phenotypically normal individuals have an affected child. What can we conclude about the parents?
1. they both carried the diesease allele
2. they are not the parents of the child
3. they are affected
4. no conclusions can be drawn
All the following are examples of Mendelian disorders except:
1. Hemophilia
2. Sickle cell anemia
3. Phenylketonuria
4. Down's syndrome
In Phenylketonuria,
I: | Phenylpyruvic acid and other derivatives are accumulated in brain resulting in mental retardation. |
II: | These are also excreted through urine because of its poor absorption by kidney. |
1. Only I is correct
2. Only II is correct
3. Both are correct
4. Both are incorrect
Which one of the following traits are controlled by genes located on the differential part of X-chromosome?
1. Porcupine skin and epidermolysis bullosa
2. Beard in man and milk glands in female
3. Color blindness and hemophilia
4. Color blindness and cystic fibrosis
Which of the following is not a hereditary disease?
1. Haemophilia.
2. Cretinism.
3. Cystic fibrosis.
4. Thalassemia.
Mendelian disorders are mainly determined by:
1. Alteration or mutation in a single gene.
2. Chromosomal gross structural changes.
3. Recombination between linked genes.
4. Jumping genes
In cases of Phenylketonuria:
1. The affected individual lacks an enzyme that converts the amino acid tyrosine into phenylalanine.
2. The affected individual makes an enzyme that converts the amino acid tyrosine into phenylalanine.
3. The affected individual makes an enzyme that converts the amino acid phenylalanine into tyrosine.
4. The affected individual lacks an enzyme that converts the amino acid phenylalanine into tyrosine.
How many diseases in the list given below are Mendelian disorders?
1. Four
2. Five
3. Six
4. Seven
Match each item in Column I with one item in Column II and chose your answer from the codes given below:
Column I Disorder |
Column II Feature |
I. Phenylketonuria II. Sickle Cell anemia III. Down's Syndrome IV. Turner's Syndrome |
(i) Rudimentary ovaries (ii) Gynecomastia (iii) Trisomy 21 (iv) Lack of enzyme PAH (v) Lack of tyrosinase (vi) Mutation GAG to GUG (vii) Mutation GUG to GAG |
1. I - v; II - vii; III - iii; IV - i
2. I - iv; II - vi; III - iii; IV - i
3. I - v; II - vi; III - iii; IV - ii
4. I - v; II - vi; III - iii; IV - i