1. Which of the following would not be a feature seen in a patient with the following karyotype ?
1. Many loops on finger tips
2. Congenital heart disease
3. Big and wrinkled tongue
4. Mucus clogging of airways
2. Which one of the following condition in human is correctly matched with its chromosomal abnormality/linkage?
(1) Klinefelter's syndrome—44 autosomes + XXY
(2) Colourblindness —Y-linked
(3) Erythroblastosis foetalis— X-linked
(4) Down syndrome—44 autosomes + XO
3. Which of the following statements are correct with respect to aneuploidy?
(i) Aneuploidy is caused due to failure of segregation of chromatids
(ii) Aneuploidy is caused by due to failure of segregation of alleles
(iii) Aneuploidy results into loss or gain of chromosomes.
(iv) Aneuploidy always results into gain of chromosomes.
(v). Down’s syndrome is caused due to aneuploidy in chromosome 21.
(1) (i), (iv) and (v)
(2) (ii), (iii) and (v)
(3) (i), (ii) and (iv)
(4) (i), (iii) and (v)
4. The abnormal hemoglobin seen in patients of sickle cell anemia is HbS. It is different in structure from the normal HbA because:
1. |
glutamic acid is replaced by valine in the beta chain |
2. |
the two beta chains are replaced by gamma chains |
3. |
it has two heme groups instead of four |
4. |
it consists of only a single globin chain and heme |
5. Which one is not a hereditary disease
1. Cystic fibrosis
2. Cretinism
3. Thalassaemia
4. Haemophilia
6. All the following statements are correct about sickle cell anaemia, except
1 The defect is caused by the substitution of glutamic acid by valine at the sixth position of beta globin chain of haemoglobin molecule
2 The mutant haemoglobin molecule stacks into crystal under low oxygen tension causing the change in shape of RBC
3 Homozygotes with two alleles for sickle cell (Hbs Hbs) enjoy some resistance to nmalaria and survive the malarial parasite more sucessfully than the normal homozygotes
4 This is an autosome linked recessive trait that can be transmitted from parents to the offspring when both the partners are carrier for the gene
7. Select incorrect option with respect to sickle cell anaemia
1. It is an example of point mutation
2. it occurs due to base substitution i.e. transition
3. Glutamic acid is replaced by Valine at sixth position in a polypeptide chain
4. Mutant haemoglobin molecule undergoes polymerization under low oxygen tension
8. Gynecomastia is an important clinical feature seen in individuals with:
1. | Klinefelter's syndrome | 2. | Turner’s syndrome |
3. | Oculocutaneous albinism | 4. | Down’s syndrome
|
9. Among fraternal twins, one baby is haemophilic while the baby's brother is normal. Which statement is true:
1. Baby is male
2. Baby is female
3. Mother is heterozygous
4. Mother is homozygous
10. Change in the sequence of nucleotides in DNA is called:
1. Mutagen
2. Mutation
3. Recombination
4. Translation
11. Placed below is a karyotype of a human being..
On the basis of this karyotype, which of the following conclusions can be drawn:
1. Normal human female
2. Person is suffering from Colour Blindness
3. Affected individual is a female with Down’s syndrome
4. Affected individual is a female with Turner’s syndrome
12. Domestic wheat, which has 42 chromosomes, is probably hexaploid (6n), whereas the haploid number in the ancestral ones was 7. Find out the right reason as to how are such plants produced?
1. Due to failure of segregation of chromatids during cell division cycle
2. Due to the gain of extra copy of chromosome
3. Due to failure of cytokinesis after telophase stage of cell division
4. Due to the loss of extra copy of chromosome
13. \(\alpha\)-thalassemia is controlled by:
1. two closely linked genes HBA1 and HBA2.
2. a single gene HBB
3. genes present on Chr-11
4. glutamic acid
14. It is possible to induce mutations artificially through the use of radiations. Which of the following is especially suitable for inducing mutations in plants?
1. X rays
2. UV rays
3. γ rays
4. PEG
15. Which of the following is not true regarding phenylketonuria?
1. |
It is inherited as an autosomal recessive condition. |
2. |
The affected individual lacks the enzyme phenylalanine hydroxylase. |
3. |
The affected individuals lack the capability of converting tyrosine to phenylalanine. |
4. |
Clinical features include mental retardation and a reduction in hair and skin pigmentation. |
16. Given below are two statements
Statement I: |
A color blind girl is rare because she will inherit the trait only when her father and maternal grandfather were color blind. |
Statement II: |
A color blind mother and normal father would have color blind sons and daughters. |
In light of the above statements, choose the most appropriate answer from the options given below :
1. Both statement I and Statement II are correct
2. Both statement I and statement II are incorrect
3. Statement I is correct but statement II is incorrect
4. Statement I is incorrect but statement II is correct
17. A heterozygous female for sickle cell anaemia (Hb
^Hb
S) :
1. |
Transmits the traits to her son only. |
2. |
Has 50% probability of transmission of the mutant gene to the progeny. |
3. |
Is considered diseased and dies before maturity. |
4. |
Is normal and does not pass the trait for sickle cell anaemia to her progeny. |
18. The figure shows the point mutation responsible for the pathogenesis of sickle cell anaemia. Identify the correct statements.
Statement I: |
The peptide chain of the haemoglobin molecule that gets mutated leading to the disease is the alpha chain. |
Statement II: |
The mRNA codon X can be GAG and the mRNA codon Y can be GUG. |
1. Only
Statement I
2. Only
Statement II
3. Both
Statement I and
Statement II
4. Neither
Statement I nor
Statement II
19. What will be true regarding the comparison of thalassemia and sickle cell anaemia?
1. |
The former is a quantitative problem of synthesising too few globin molecules while the latter is a qualitative problem of synthesising an incorrectly functioning globin. |
2. |
The former is a qualitative problem of synthesising too few globin molecules while the latter is a quantitative problem of synthesising an incorrectly functioning globin. |
3. |
Both disorders are qualitative problems of synthesising too few globin molecules. |
4. |
Both disorders are quantitative problems of synthesising too few globin molecules. |
20. Study the given figures and select the correct statements.
Statement I: |
Part A shows the common clinical features of Down’s syndrome. |
Statement II: |
Part B shows the characteristic karyotype of Down’s Syndrome. |
1. Only
Statement I
2. Only
Statement II
3. Both
Statement I and
Statement II
4. Neither
Statement I nor
Statement II
21. Assertion(A): Color blindness is a sex-linked disorder.
Reason(R): Genes that lead to red-green color blindness are on the X chromosome.
Choices for Assertions and reasons:
1. Both (A) and (R) are true and (R) is the correct explanation of (A).
2. Both (A) and (R) are true, but (R) is not the correct explanation of (A).
3. (A) is true, but (R) is false.
4. (A) is false, but (R) is true.
22. Non-disjunction in meiosis results in:
1. trisomy
2. normal diploid
3. gene mutation
4. None of these
23. AB blood group shows:
1. Codominance
2. incomplete dominance
3. polygenic inheritance
4. pleiotropy
24. Consider the two statements:
Statement I: |
Thalassemia is a qualitative problem of synthesising an incorrectly functioning globin. |
Statement II: |
Sickle cell anaemia is a quantitative problem of synthesising too few globin molecules while the latter. |
1. Statement I is correct; Statement II is correct
2. Statement I is correct; Statement II is incorrect
3. Statement I is incorrect; Statement II is correct
4. Statement I is incorrect; Statement II is incorrect
25. Consider the given two statements:
Assertion(A): |
The possibility of a female becoming a haemophilic is extremely rare. |
Reason(R): |
In haemophilia, a single protein that is a part of the cascade of proteins involved in the clotting of blood is affected. |
1. |
(A) is True but (R) is False |
2. |
(A) is False but (R) is True |
3. |
Both (A) and (R) are True and (R) is the correct explanation of (A) |
4. |
Both (A) and (R) are True but (R) is not the correct explanation of (A) |
26. Consider the given two statements:
Assertion: |
Aneuploidy is the presence of an abnormal number of chromosomes in a cell where the changed number is not an exact multiple of the base number. |
Reason: |
Aneuploidy originates during cell division when the chromosomes do not separate properly between the two cells (nondisjunction). |
1. |
(A) is False but (R) is True |
2. |
(A) is True but (R) is False |
3. |
Both (A) and (R) are True and (R) is the correct explanation of (A) |
4. |
Both (A) and (R) are True but (R) is not the correct explanation of (A) |
27. The karyotype shown below is of a person affected with:
1. Klinefelter’s syndrome
2. Turner’s syndrome
3. Down’s syndrome
4. Edward’s syndrome
28. How many of the given statements are correct?
I: |
F1 resembled either of the two parents in co-dominance |
II: |
F1 was in-between in complete dominance. |
III: |
F1 generation resembles both parents in incomplete dominance. |
1. Only I
2. Only II and III
3. None
4. I, II and III
29. Starch synthesis in pea seeds is controlled by one gene. What will be true?
Statement I: |
BB homozygotes produce large starch grains, Bb heterozygotes produce large starch grains and bb homozygotes produce smaller starch grains. |
Statement II: |
BB homozygotes produce round seeds, Bb heterozygotes produce oval seeds and bb homozygotes produce wrinkled seeds. |
1. |
Statement I is correct; Statement II is correct |
2. |
Statement I is correct; Statement II is incorrect |
3. |
Statement I is incorrect; Statement II is incorrect |
4. |
Statement I is incorrect; Statement II is correct |
30. The β-globin chains of hemoglobin are encoded by:
1. |
a single gene on chromosome 11 |
2. |
two closely linked genes on chromosome 16 |
3. |
a single gene on chromosome 16 |
4. |
two closely linked genes on chromosome 11 |
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