#29-Mendelian-Disorders-Sickle-Cell-Anemia
(Botany) > Principles of Inheritance & Variation

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Sickle cell anaemia results from.

1. A chromosomal aberration

2. Non disjunction of autosome

3. A point mutation

4. Blood transfusion reaction

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Identify the incorrect statement:

(1) In addition to recombination, mutation is another phenomeonon that leads to variation in DNA.

(2) Chromosomal aberrations are commonly observed in cancer cells.

(3) A classical example of a point mutation is sickle cell anaemia.

(4) Non ionising radiations cannot be mutations. 

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Given below is the initial amino acids of the beta chain of a hemoglobin molecule. What will be true about this hemoglobin molecule ?

1. The RBCs carrying this molecule will undergo sickling at high oxygen tension
2. The RBCs carrying this molecules will undergo sickling at low oxygen tension
3. There will be a quantitative decrease in the synthesis of this molecule
4. This is normal beta chain of the hemoglobin molecule
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Sickle cell anaemia has not been eliminated from the African population because :

(1) it is controlled by recessive genes

(b) it is not a fatal disease

(3) it provides immunity against malaria

(4) it is controlled by a dominant genes

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Sickle cell anaemia is example of 

(1) sex-linked inheritance

(2) deficiency disease

(3) autosomal heritable disease

(4) infectious disease

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