Q. No.The first clinical gene therapy trial was given in 1990 to a 4 year girl with:
1.
Alpha – 1 antitrypsin deficiency
2.
Cystic fibrosis
3.
Adenosine deaminase deficiency
4.
Chronic myeloid leukemia
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ELISA is based on the principle of:
1. Antibody opsonization
2. Antigen-antibody interaction
3. Radioactive immune assay
4. Creation of recombinant DNA
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The transgenic cow, Rosie, produced milk that:
| 1. | Contained human beta lactalbumin |
| 2. | contained interferons to treat viral infections |
| 3. | contained Alpha – 1 antitrypsin |
| 4. | Is protein enriched |
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Recombinant therapeutic [used for treatment] products are available for all the following disorders except:
| 1. | Hemophilia A | 2. | Pituitary dwarfism |
| 3. | Diabetes insipidus | 4. | Anemia due to renal failure |
Electroporation is:
| 1. | the process of separating charged molecules through a gel maintained in an electric field |
| 2. | the process of combining foreign DNA to an electrically charged vector molecule |
| 3. | the process of introducing DNA into cells by the application of high-voltage pulses |
| 4. | the process of protoplast fusion by the application of high-voltage pulses |
Restriction endonucleases present in bacterial cells provide an advantage to the cell because these enzymes:
| 1. | can identify the mutated sequences on the chromosomal DNA and help in their repair |
| 2. | selectively bind to particular nucleotide sequences that may appear in viral DNA preventing its replication in the cell |
| 3. | can cut the plasmid DNA of the bacterial cell that allows them to recombine foreign DNA into their plasmid DNA |
| 4. | help the bacterium take up foreign DNA from their environment and combine it into their genome |
Match each item in Column I with one in Column II and select the answer from the codes given below:
|
Column I |
Column II |
||
|
A. |
Bioprospecting |
a. |
the process of discovery and commercialization of new products based on biological resources |
|
B. |
Biopiracy |
b. |
the exploitative patenting of already widely used natural resources, such as plant varieties, by commercial entities |
|
C. |
Bioremediation |
c. |
a process that uses microorganisms or their enzymes to treat polluted sites for regaining their original condition |
|
D. |
Biofortification |
d. |
the process by which the nutritional quality of food crops is improved through agronomic practices, conventional plant breeding, or modern biotechnology |
Codes
| Options: | A | B | C | D |
| 1. | a | b | c | d |
| 2. | a | b | d | c |
| 3. | b | a | c | d |
| 4. | b | a | d | c |
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Antisense technology:
| 1. | selectively blocks the expression of a gene. |
| 2. | combines genetic material from different species. |
| 3. | combines organelles and cells. |
| 4. | alters or transfers cells. |
A direct target for gene therapy would include all the following cells except:
| 1. | erythrocytes | 2. | muscle fibers |
| 3. | hepatocytes | 4. | vascular endothelium |
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