Q. No.Nondisjunction of a pair of homologous chromosomes occurs during the anaphase of meiosis I. The four gametes produced as a result of this nondisjunction event will be:
1.
n + 1; n + 1; n - 1; n - 1
2.
n + 1; n - 1; n; n
3.
n + 1; n - 1; n - 1; n - 1
4.
n + 1; n + 1; n; n
The inheritance of the trait shown in the given pedigree most likely is:
| 1. | Autosomal recessive | 2. | Autosomal dominant |
| 3. | Sex-linked recessive | 4. | Sex-linked dominant |
The inheritance of genes finds a parallel with the behavior of chromosomes, especially during cell division for gamete formation. Such parallels include:
| I: | they are both present in pairs in all diploid cells and one of the pairs is present in the gamete |
| II: | they both undergo segregation during meiosis. |
| III: | their copy numbers in the cell decrease after meiosis, and increase during fertilization. |
| IV: | they are both copied during the S phase of the cell cycle. |
| 1. | I, II and III only | 2. | I, II and IV only |
| 3. | II, III and IV only | 4. | I, II, III and IV |
Identify the condition where the following karyotype is expected:
1. Klinefelter’s syndrome
2. Cri du chat syndrome
3. Turner’s syndrome
4. Down’s syndrome
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Which of the following experiments can show a gene to be located on the X-chromosome?
I. set up reciprocal crosses
II. set up two point test cross
1. Only I
2. Only II
3. Neither I nor II
4. Both I & II
A man and woman who both have normal pigmentation but both having an albino parent have two children both with normal pigmentation. What is the probability that their child might be an albino?
1. 0
2. ¼
2. ½
3. ¾
Identify the chromosomal aberration:
| 1. | Inversion | 2. | Reciprocal translocation |
| 3. | Deletion | 4. | Duplication |
Sons inherit the following exclusively from their mothers:
I. SR Y gene
II. X chromosome
III. Mitochnodrial DNA
1. Only II
2. Only I and III
3. Only II and III
4. Only III
A couple comes to you for genetic counselling. Both have a sister affected with albinism but all other members are normal. Your advice regarding the risk of their child being affected with albinism would be:
| 1. | They must both be heterozygotes so their risk of having an affected child is ¼. |
| 2. | They might both be heterozygotes so they should get tested to see if they carry the disease allele or not. |
| 3. | Since neither one of them is affected, they are not at risk of having an affected child. |
| 4. | You can't give them any firm answers because you don't know their genotypes. |
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