Q. No.What would be true for the mutation that leads to sickle cell anemia ?
I:
Is a base substitution.
II:
Is a deleterious mutation.
III:
Is a missense mutation.
1.
I and II only
2.
I and III only
3.
II and III only
4.
I, II, and III
All the following regarding RNA splicing are correct except:
1. Some introns can splice themselves out.
2. Splicing is required for some tRNAs.
3. The final step of splicing is formation of a phosphodiester linkage.
4. Introns often have a specific function after they are removed.
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The essential difference between DNA replication in eukaryotes and prokaryotes will be:
1. A high % of AT base pairs in Ori region of eukryotic DNA.
2. Bidirectional movement of replication fork in eukaryotes.
3. Eukaryotes contain several different DNA polymerases.
4. Telomerase required to replicate the ends of eukaryotic chromosomes.
Mutations can lead to incorporation of wrong amino acid into the polypeptide chain. This is least likely to occur when there is:
1. a change in the wobble base of the codon.
2. a mistake in amino acid attachment to the tRNA.
3. a change in the third base of the anticodon.
4. a gene mutation involving the first base of the codon.
If there is a change in chromosome number [gain or loss] the type of mutation is called:
1. Structural mutation
2. Chromosome mutation
3. Genome mutation
4. Single-gene mutation
An inducible operon like the ‘lac operon’ will be characterized by:
| 1. | A repressor protein, which is bound to DNA in absence of any other factor. |
| 2. | A repressor protein, which is bound to DNA in the presence of a corepressor. |
| 3. | An activator protein, which is bound to DNA in absence of any other factor. |
| 4. | An activator protein, which is bound to DNA only in the absence of an inhibitor. |
The one gene — one enzyme hypothesis basically means that:
1. Every gene encodes a protein.
2. Each structural gene encodes an essential metabolic enzyme.
3. Each structural protein is encoded by a single gene.
4. Genes are always expressed as enzymes
All the following are structural genes in a lac operon except:
1. lacA
2. lac I
3. lacY
4. lacZ
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Expression of the lac operon was completely repressed. This will lead to:
| 1. | The low level of lacZ, lacY, and lacA gene expression will continue. |
| 2. | Allolactose would accumulate within the cell and become toxic. |
| 3. | Lactose would not be converted into the inducer and the operon could not be induced. |
| 4. | The cell will not be able to use glucose as well. |
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What type of changes will lead to a frameshift mutation?
| I: | A transition | II: | A transversion | III: | A deletion of 3 bp |
| 1. | I and II only | 2. | III only |
| 3. | I, II, and III | 4. | None |
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