In the given pedigree chart, select the correct statement:

(1) A & B are twins

(2) A is younger than B

(3) B is younger than A

(4) Can’t determine the age of A & B

Which of the following is the sex linked disease? 

(1) Sickle cell anaemia

(2) Haemophilia

(3) Cystic fibrosis

(4) Phenylketonuria

Mendelian disorders are caused by

(1) Mutation in the single chromosome

(2) Mutation in the single gene

(3) Polyploidy

(4) Aneuploidy

Myotonic dystrophy is

(1) Autosomal recessive trait

(2) Autosomal dominant trait

(3) X- linkeddominant trait

(4) X- linked recessive trait

Boy born to a physically normal couple has been diagnosed with a genetic disorder, this could be

(1) Y- linked trait.

(2) Autosomal dominant trait

(3) X- linked dominant trait

(4) X- linked recessive trait

Which of the following disorder is associated with Queen Victoria?

(1) Sickle cell anaemia

(2) Haemophilia

(3) Huntington's Disease

(4) Myotonic dystrophy

Which of the following is least probable? 

(1) Female child with Sickle cell anaemia

(2) Male child with haemophilia

(3) Carrier female for haemophilia

(4) Female child with haemophilia

Which of the following disorder can’t be transmitted from a single diseased parent? 

(1) Sickle cell anaemia

(2) Haemophilia

(3) Colour Blindness

(4) Myotonic dystrophy

Which of the following genotypes could cause Sickle cell anaemia? 

(1) Hbˢ + Hbᴬ

(2) Hbᴬ+ Hbᴬ

(3) Hbˢ + Hbˢ

(4) Both ‘A’ and ‘C’.

Sickle cell anaemia is caused by

(1) Substitution of valine by glutamic acid at 6^th position in the polypeptide.

(2) Substitution of valine by glycine at 4^th position in the polypeptide.

(3) Substitution of glutamic acid by valine at 4^th position in the polypeptide.

(4) Substitution of glutamic acid by valine at 6^th position in the polypeptide.