Mendelian disorders are caused by

(1) Mutation in the single chromosome

(2) Mutation in the single gene

(3) Polyploidy

(4) Aneuploidy

Myotonic dystrophy is

(1) Autosomal recessive trait

(2) Autosomal dominant trait

(3) X- linkeddominant trait

(4) X- linked recessive trait

Boy born to a physically normal couple has been diagnosed with a genetic disorder, this could be

(1) Y- linked trait.

(2) Autosomal dominant trait

(3) X- linkeddominant trait

(4) X- linked recessive trait

Which of the following disorder is associated with Queen Victoria?

(1) Sickle cell anaemia

(2) Haemophilia

(3) Huntington's Disease

(4) Myotonic dystrophy

Which of the following is least probable? 

(1) Female child with Sickle cell anaemia

(2) Male child with haemophilia

(3) Carrier female for haemophilia

(4) Female child with haemophilia

Which of the following disorder can’t be transmitted from a single diseased parent? 

(1) Sickle cell anaemia

(2) Haemophilia

(3) Colour Blindness

(4) Myotonic dystrophy

Which of the following genotypes could cause Sickle cell anaemia? 

(1) Hbˢ + Hbᴬ

(2) Hbᴬ+ Hbᴬ

(3) Hbˢ + Hbˢ

(4) Both ‘A’ and ‘C’.

Sickle cell anaemia is caused by

(1) Substitution of valine by glutamic acid at 6^th position in the polypeptide.

(2) Substitution of valine by glycine at 4^th position in the polypeptide.

(3) Substitution of glutamic acid by valine at 4^th position in the polypeptide.

(4) Substitution of glutamic acid by valine at 6^th position in the polypeptide.

Elongated sickle like structure of RBC is produced by

(1) Platelets deposition on the outer surface of RBC

(2) Reduced surface tension

(3) Polymerisation of mutant haemoglobin under high oxygen tension.

(4) Polymerisation of mutant haemoglobin under low oxygen tension.

Sickle cell anaemic person will have 

(1) Abnormal beta globin chain and sickle shaped RBC

(2) Normal beta globin chain and sickle shaped RBC

(3) Abnormal beta globin chain and biconcave RBC

(4) Normal beta globin chain and biconcave RBC