Which of the following genotypes could cause Sickle cell anaemia? 

(1) Hbˢ + Hbᴬ

(2) Hbᴬ+ Hbᴬ

(3) Hbˢ + Hbˢ

(4) Both ‘A’ and ‘C’.

Sickle cell anaemia is caused by

(1) Substitution of valine by glutamic acid at 6^th position in the polypeptide.

(2) Substitution of valine by glycine at 4^th position in the polypeptide.

(3) Substitution of glutamic acid by valine at 4^th position in the polypeptide.

(4) Substitution of glutamic acid by valine at 6^th position in the polypeptide.

Elongated sickle like structure of RBC is produced by

(1) Platelets deposition on the outer surface of RBC

(2) Reduced surface tension

(3) Polymerisation of mutant haemoglobin under high oxygen tension.

(4) Polymerisation of mutant haemoglobin under low oxygen tension.

Sickle cell anaemic person will have 

(1) Abnormal beta globin chain and sickle shaped RBC

(2) Normal beta globin chain and sickle shaped RBC

(3) Abnormal beta globin chain and biconcave RBC

(4) Normal beta globin chain and biconcave RBC

Mental retardation is associated with

(1) Klinefelter’s syndrome

(2) Haemophilia

(3) Cystic fibrosis

(4) Phenylketonuria

Study the pedigree chart given below to identify the disorder

(1) Sickle cell anaemia

(2) Haemophilia

(3) Myotonic dystrophy

(4) Phenylketonuria

What does the given pedigree chart shows? 

(1) Sex-linked recessive trait

(2) Sex-linked dominant trait

(3) Inheritance of Sickle cell anaemia

(4) Inheritance of autosomal dominant trait

Which of the following statements are correct with respect to aneuploidy? 

(i) Aneuploidy is caused due to failure of segregation of chromatids

(ii) Aneuploidy is caused by due to failure of segregation of alleles

(iii) Aneuploidy results into loss or gain of chromosomes.

(iv) Aneuploidy always results into gain of chromosomes.

(v). Down’s syndrome is caused due to aneuploidy in chromosome 21.

(1) (i), (iv) and (v)

(2) (ii), (iii) and (v)

(3) (i), (ii) and (iv)

(4) (i), (iii) and (v)

Which of the following statements are correct?

(i) Polyploidy is caused due to failure of cytokinesis after telophase.

(ii) polyploidy results into increase in number of autosomes

(iii) Turner’s syndrome is an example of polyploidy

(iv) polyploidy results into an increase in a whole set of chromosomes

(1) (i) and (ii)

(2) (i) and (iii)

(3) (ii) and (iii)

(4) (i) and (iv)

Sex determination in Honey bee depends upon-

(1) Number of sets of chromosomes present in parents

(2) Number of sets of chromosomes present in progenies

(3) Number of sets of genes present in parents

(4) Number of sets of genes present in progenies