The major approaches used in HGP for identifying genes were

(1) BLAST

(2) Expressed Sequence Tags

(3) Sequence annotation

(4) b and c

Which of the following were not used in HGP?

(1)Vectors like BAC and YAC

(2) Hosts like plants and animals

(3)Protein sequencers

(4)DNA sequencers

Frederick Sanger is credited for the invention of

(1)DNA sequencing method

(2)Protein sequencing method

(3)Both

(4)RNA sequencing method

The last chromosome to be sequenced in HGP was

(1) the last chromosome of the human genome

(2)the first chromosome of the human genome

(3)chromosome I

(4)Both b and c

The number of autosomal chromosomes in the human beings are

(1) 44

(2) 22

(3) 2

(4) 1

How many of the following were the features of the Human Genome

1. 99.9% bases are present are exactly same in all humans

2. all sequences were found to be coding sequences

3. Repeated sequences make up very large portion of the human genome

4. Repeated sequences are useful for chromosome structure, dynamics and evolution

5. The maximum no of genes were found to be present at the chromosome which was last sequenced

6. The fewest no of genes were found to be present at the chromosome which is present in male only.

(1) 1

(2) 2

(3) 3

(4) 5

The locations in human genome which differ by a single base difference is known as

(1)Single nucleotide mutation

(2)Single nucleotide polymorphism

(3)RFLP

(4)Single nucleotide polymorphogenesis

The largest known human gene is

(1) Dystrophin protein gene on X chromosome

(2) Sry gene on Y chromosome

(3) Dystropin protein gene on Y chromosome

(4) Sry gene on X chromosome

If an E.coli with heavy DNA allow to grow for 80 minutes in a culture medium of 14 NH 4

Cl, then what would be the proportion of heavy,light and hybrid densities DNA molecule

respectively?

1. 1/16 : 1/16 : 14/16

2. 0/16 : 14/16 : 2/16

3. 1/16 : 14/16 : 1/16

4. 1/8 : 2/8 : 6/8

Alec Jeffrey’s name is associated with

a. DNA sequencing

b. DNA fingerprinting

c. RNA sequencing

d. Gene cloning