Sickle Cell Anaemia | Thalassemia | ||
I | Mode of inheritance | Autosomal recessive | Sex linked recessive |
II | Cause | Substitution of valine by glutamic acid due to a single base substitution at the sixth codon of the beta globin chain | Mutation or deletion of genes located on chromosomes 11 or 16 |
III | Effect on haemoglobin | Qualitative – incorrectly functioning globin | Quantitative – synthesis of too few haemoglobin molecules |
I. | Down’s syndrome | Trisomy 21; Simian palmar crease, Furrowed tongue, Mental retardation |
II. | Klinefelter’s syndrome | 47,XXY; Genetically female, gynaecomastia and sterility |
III. | Turner’s syndrome | 45, XO; genetically male, Rudimentary ovaries, lack of secondary sexual characters |
Assertion (A): | Mendel's law of independent assortment holds good for genes that are located closely on the same chromosome. |
Reason (R): | Closely located genes assort independently. |
1. | (A) is not correct and (R) is not correct |
2. | Both (A) and (R) are correct and (R) is the correct explanation of (A) |
3. | Both (A) and (R) are correct but (R) is not the correct explanation of (A) |
4. | (A) is correct and (R) is not correct |
1. | more than two genes affecting a single character. |
2. | presence of several alleles of a single gene controlling a single crossover. |
3. | presence of two alleles, each of the two genes controlling a single trait. |
4. | a single gene affecting multiple phenotypic expressions. |
1. | Henking | 2. | Thomas Hunt Morgan |
3. | Sutton and Boveri | 4. | Alfred Sturtevant |
A. | This disorder was first described by Langdon Down (1866). |
B. | Such an individual has overall masculine development. However, the feminine development is also expressed. |
C. | The affected individual is short statured. |
D. | Physical, psychomotor and mental development is retarded. |
E. | Such individuals are sterile. |
1. | A and E only | 2. | A and B only |
3. | C and D only | 4. | B and E only |