1. | 2. | ||
3. | 4. |
Sickle Cell Anaemia | Thalassemia | ||
I | Mode of inheritance | Autosomal recessive | Sex linked recessive |
II | Cause | Substitution of valine by glutamic acid due to a single base substitution at the sixth codon of the beta globin chain | Mutation or deletion of genes located on chromosomes 11 or 16 |
III | Effect on haemoglobin | Qualitative – incorrectly functioning globin | Quantitative – synthesis of too few haemoglobin molecules |
I. | Down’s syndrome | Trisomy 21; Simian palmar crease, Furrowed tongue, Mental retardation |
II. | Klinefelter’s syndrome | 47,XXY; Genetically female, gynaecomastia and sterility |
III. | Turner’s syndrome | 45, XO; genetically male, Rudimentary ovaries, lack of secondary sexual characters |
Assertion (A): | Mendel's law of independent assortment holds good for genes that are located closely on the same chromosome. |
Reason (R): | Closely located genes assort independently. |
1. | (A) is not correct and (R) is not correct |
2. | Both (A) and (R) are correct and (R) is the correct explanation of (A) |
3. | Both (A) and (R) are correct but (R) is not the correct explanation of (A) |
4. | (A) is correct and (R) is not correct |